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Publikationen Publications

Publikationen 2019 Publications 2019

Friedrich S, Lüders S, Glimm AM, Werner SG, Schmittat G, Burmester GR, Backhaus M, Riemekasten G, Ohrndorf S. Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis. Arthritis Res Ther. (2019) PMID: 30987674

Ohrndorf S, Boer AC, Boeters DM, Ten Brinck RM, Burmester GR, Kortekaas MC, van der Helm-van Mil AHM. Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia. Arthritis Res Ther. (2019) PMID: 30764862

Skapenko A, Smolen J, Kavanaugh A, Arora V, Kupper H, Schulze-Koops H. Genetic Markers Are Associated With Clinical and Radiographic Response in Patients With Rheumatoid Arthritis Who Received Adalimumab Plus Methotrexate Combination Therapy or Methotrexate Monotherapy in the OPTIMA Study. Clin. Exp. Rheumatol. (2019) PMID: (in press)

Toldi G, Batel P, Baráth S, Szerémy P, Apjok A, Filkor K, Szántó S, Szűcs G, Szamosi S, Häupl T, Grützkau A, Szekanecz Z. Peripheral Lymphocyte Multidrug Resistance Activity as a Predictive Tool of Biological Therapeutic Response in Rheumatoid Arthritis. J Rheumatol. (2019) PMID: 30709954

Sewerin P, Schleich C, Brinks R, Müller-Lutz A, Fichter F, Eichner M, Schneider M, Ostendorf B, Vordenbäumen S. Synovial perfusion assessed by dynamic contrast-enhanced MRI is associated to treatment response, remission, and cartilage quality in rheumatoid arthritis. J Rheumatol. (2019) PMID: 30877219

Frenken M, Schleich C, Brinks R, Abrar DB, Goertz C, Schneider M, Ostendorf B, Sewerin P. The value of the simplified RAMRIS-5 in early RA patients under methotrexate therapy using high-field MRI. Arthritis Res Ther. (2019) PMID: 30642376

Sewerin P, Müller-Lutz A, Abrar DB, Odendahl S, Eichner M, Schneider M, Ostendorf B, Schleich C. Prevention of the progressive biochemical cartilage destruction under methotrexate therapy in early rheumatoid arthritis. Clin Exp Rheumatol. (2019) PMID: 29998824

Publikationen 2018 Publications 2018

Sewerin P, Mueller-Lutz A, Schneider M, Schleich C, Ostendorf B, Vordenbäumen S. Dynamic MRI in Rheumatoid Arthritis for the Assessment of Synovitis Promoting Cartilage Loss. Arthritis Rheumatol. (2018) Link

Leipe J, Christ LA, Arnoldi AP, Mille E, Berger F, Heppt M, Goldscheider I, Kauffmann-Guerrero D, Huber RM, Dechant C, Berking C, Schulze-Koops H, Skapenko A. Characteristics and treatment of new onset arthritis after checkpoint inhibitor therapy. RMD Open (2018) PMID: 30167328

Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, Toupet K, Mausset-Bonnefont AL, Cren M, Robin M, Georgel P, Nehmar R, Taams L, Grün JR, Grützkau A, Häupl T, Pers YM, Jorgensen C, Duroux-Richard I, Courties G, Apparailly F. Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis. Theranostics. (2018) PMID: 30613275

Schulte-Wrede U, Sörensen T, Grün JR, Häupl T, Hirseland H, Steinbrich-Zöllner M, Wu P, Radbruch A, Poddubnyy D, Sieper J, Syrbe U, Grützkau A. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res Ther. (2018) PMID: 30157966

Pongratz G, Lowin T, Sewerin P, Zaucke F, Jenei-Lanzl Z, Pauly T, Ostendorf B, Schneider M. Tryptophan metabolism in rheumatoid arthritis is associated with rheumatoid factor and predicts joint pathology evaluated by the Rheumatoid Arthritis MRI Score (RAMRIS). Clin Exp Rheumatol. (2018) PMID: 30557125

Mori V, Sawicki LM, Sewerin P, Eichner M, Schaarschmidt BM, Oezel L, Gehrmann S, Bittersohl B, Antoch G, Schleich C. Differences of radiocarpal cartilage alterations in arthritis and osteoarthritis using morphological and biochemical magnetic resonance imaging without gadolinium-based contrast agent administration. Eur Radiol. (2018) PMID: 30542752

Sewerin P, Schleich C, Vordenbäumen S, Ostendorf B. Update on imaging in rheumatic diseases: cartilage. Clin Exp Rheumatol. (2018) PMID: 30296981

Poddubnyy D, Listing J, Haibel H, Knüppel S, Rudwaleit M, Sieper J. Functional relevance of radiographic spinal progression in axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort. Rheumatology (Oxford) (2018) PMID: 29373733

van den Berg R, Ohrndorf S, Kortekaas MC, van der Helm-van Mil AHM. What is the value of musculoskeletal ultrasound in patients presenting with arthralgia to predict inflammatory arthritis development? A systematic literature review. Arthritis Res Ther. (2018) PMID: 30305156

Häupl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlmüller B, Schulze-Koops H, Burmester GR. Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark. Z Rheumatol. (2018) PMID: 29691690

Zhong J, Scholz T, Yau ACY, Guerard S, Hüffmeier U, Burkhardt H, Holmdahl R. Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes. Sci Adv. (2018) PMID: 29774240

Sewerin P. Rheumatoid Arthritis Magnetic Resonance Imaging Score Predicts Therapy Response: Results of the German ArthroMark Cohort. J Rheumatol. (2018) PMID: 29606664

Schwedler C, Häupl T, Kalus U, Blanchard V, Burmester GR, Poddubnyy D, Hoppe B. Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity. Arthritis Res Ther. (2018) PMID: 29540200

Mansmann U. Big data from clinical routine. Z Rheumatol. (2018) PMID: 29453548

Sewerin P, Ostendorf B, Hueber AJ, Kleyer A. Big data in imaging. Z Rheumatol. (2018) PMID: 29411097

Bonin-Andresen M, Smiljanovic B, Stuhlmüller B, Sörensen T, Grützkau A, Häupl T. Relevance of big data for molecular diagnostics. Z Rheumatol. (2018) PMID: 29520680

Burmester GR, Häupl T. Big data-also relevant in rheumatology? Z Rheumatol. (2018) PMID: 29619762

Popadić D, Heßelbach K, Richter-Brockmann S, Kim GJ, Flemming S, Schmidt-Heck W, Häupl, Bonin-Andresen M, Dornhof R, Achten C, Günther S, Humar M, Merfort I. Gene expression profiling of human bronchial epithelial cells exposed to fine particulate matter (PM2.5) from biomass combustion. Toxicol Appl Pharmacol. (2018) PMID: 29596927

Publikationen 2017 Publications 2017

Friedrich S, Lüders S, Werner SG, Glimm AM, Burmester GR, Riemekasten G, Backhaus M, Ohrndorf S. Disturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study. Arthritis Res Ther. (2017) PMID: 28482872

Lüders S, Friedrich S, Ohrndorf S, Glimm AM, Burmester GR, Riemekasten G, Backhaus M. Detection of severe digital vasculopathy in systemic sclerosis by colour Doppler sonography is associated with digital ulcers. Rheumatology (Oxford) (2017) PMID: 28340234

Witt M, Frielinghausen J, Mueller R, Mueller F, Proft F, Schulze-Koops H, Grunke M, Clevert DA. Evaluation of a Novel Semi-Automated Ultrasound System for the Detection of Synovitis: A Prospective Study involving 45 Patients with Rheumatoid Arthritis. Ultrasound Int Open (2017)PMID: 27921093

Leipe J, Schulze-Koops H. Pathogenetic concepts of joint diseases. In: Pietschmann P (ed) Principles of bone and joint research. Springer (2017) Link

Protopopov M, Sieper J, Haibel H, Listing J, Rudwaleit M, Poddubnyy D. Relevance of structural damage in the sacroiliac joints for the functional status and spinal mobility in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Res Ther. (2017) PMID: 29065931

Hartl A, Sieper J, Syrbe U, Listing J, Hermann KG, Rudwaleit M, Poddubnyy D. Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial. Arthritis Res Ther. (2017) PMID: 28619118

Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. (2017) PMID: 28679953

Sewerin P, Vordenbaeumen S, Brinks R, Ostendorf B. Prospective MRI score to predict negative EULAR response in patients with rheumatoid arthritis (RA) before therapy-escalation to a biological therapy. Ann Rheum Dis. (2017) PMID: 28283516

Sewerin P, Vordenbaeumen S, Hoyer A, Brinks R, Buchbender C, Miese F, Schleich C, Klein S, Schneider M, Ostendorf B. Silent progression in patients with rheumatoid arthritis: is DAS28 remission an insufficient goal in RA? Results from the German Remission-plus cohort. BMC Musculoskelet Disord. (2017) PMID: 28420375

Scholz T, Weigert A, Brüne B, Sadik CD, Böhm B, Burkhardt H. GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency. PLoS One. (2017) PMID: 28777803

Uebe S, Ehrlicher M, Ekici AB, Behrens F, Böhm B, Homuth G, Schurmann C, Völker U, Jünger M, Nauck M, Völzke H, Traupe H, Krawczak M, Burkhardt H, Reis A, Hüffmeier U. Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients. BMC Med Genet. (2017) PMID: 28835222

Smiljanovic B, Radzikowska A, Kuca-Warnawin E, Kurowska W, Grün JR, Stuhlmüller B, Bonin-Andresen M, Schulte-Wrede U, Sörensen T, Kyogoku C, Bruns A, Hermann S, Ohrndorf S, Aupperle K, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Maslinski W, Häupl T. Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint. Ann Rheum Dis. (2017) PMID: 29191820

Smiljanovic B, Bonin-Andresen M, Stuhlmüller B, Sörensen T, Grützkau A, Häupl T. Comment on "Single cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors." (2017) Link

Heßelbach K, Kim GJ, Flemming S, Häupl T, Bonin-Andresen M, Dornhof R, Günther S, Merfort I, Humar M. Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion. Epigenetics (2017) PMID: 28742980

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Casadonte R, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Sunitsch S, Tikhilov R, Morawietz L. 15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics. Pathol Res Pract. (2017) PMID: 28687159

Stich S, Loch A, Park SJ, Häupl T, Ringe J, Sittinger M. Characterization of single cell derived cultures of periosteal progenitor cells to ensure the cell quality for clinical application. PLoS One (2017) PMID: 28562645

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Tikhilov R, Morawietz L. Fifteen years of the histopathological synovitis score: Review and further developments of a diagnostic score. Z Rheumatol. (2017) PMID: 28470440

Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN. Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). J Cell Physiol. (2017) PMID: 27636101

Strauß R, Rose T, Flint SM, Klotsche J, Häupl T, Peck-Radosavljevic M, Yoshida T, Kyogoku C, Flechsig A, Becker AM, Dao KH, Radbruch A, Burmester GR, Lyons PA, Davis LS, Hiepe F, Grützkau A, Biesen R. Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options. J Mol Med. (2017) PMID: 28357476

Smiljanovic B, Radzikowska A, Kuca-Warnawin E, Kurowska W, Sörensen T, Stuhlmüller B, Bonin-Andresen M, Grün JR, Burmester GR, Radbruch A, Grützkau A, Maslinski W, Häupl T. Increased Turnover of Monocytes in Patients with Rheumatoid Arthritis Identified by Transcriptome and Cytometric Profiling. Ann Rheum Dis. (2017) Link

Publikationen 2016 Publications 2016

Vastesaeger N, Kutzbach AG, Amital H, Pavelka K, Lazaro MA, Moots RJ, Wollenhaupt J, Zerbini CA, Louw I, Combe B, Beaulieu A, Schulze-Koops H, Dasgupta B, Fu B, Huyck S, Weng HH, Govoni M, Durez P. Prediction of remission and low disease activity in disease-modifying anti-rheumatic drug-refractory patients with rheumatoid arthritis treated with golimumab. Rheumatology (2016) PMID: 27114562

Proft F, Grunke M, Reindl C, Mueller F, Kriegmair M, Leipe J, Weinert P, Schulze-Koops H, Witt M. The influence of long distance running on sonographic joint and tendon pathology: results from a prospective study with marathon runners. BMC Musculoskelet Disord. (2016) PMID: 27400865

Poddubnyy D, Protopopov M, Haibel H, Braun J, Rudwaleit M, Sieper J. High disease activity according to the Ankylosing Spondylitis Disease Activity Score is associated with accelerated radiographic spinal progression in patients with early axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort. Ann Rheum Dis. (2016) PMID: 27125522

Glimm AM, Werner SG, Burmester GR, Backhaus M, Ohrndorf S. Analysis of distribution and severity of inflammation in patients with osteoarthritis compared to rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound: a pilot study. Ann Rheum Dis. (2016) PMID: 26311723

Haupt S, Söntgerath VS, Leipe J, Schulze-Koops H, Skapenko A. Methylation of an intragenic alternative promoter regulates transcription of GARP. Biochim Biophys Acta. (2016) PMID: 26584734

Stuhlmüller B, Mans K, Tandon N, Bonin-Andresen M, Smiljanovic B, Sörensen T, Schendel P, Martus P, Listing J, Detert J, Backhaus M, Neumann T, Winchester RJ, Burmester GR, Häupl T. Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis. Clin Immunol. (2016) PMID: 27570220

Duroux-Richard I, Roubert C, Ammari M, Présumey J, Grün JR, Häupl T, Grützkau A, Lecellier CH, Boitez V, Codogno P, Escoubet J, Pers YM, Jorgensen C, Apparailly F. miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics. Blood. (2016) PMID: 27702798

Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN. Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). J Cell Physiol. (2016) PMID: 27636101

Löhr S, Uebe S, Behrens F, Böhm B, Köhm M, Traupe H, Oji V, Burkhardt H, Reis A, Hüffmeier U. Association analysis of psoriasis vulgaris and psoriatic arthritis with loss-of-function mutations in IL36RN in German patients. Br J Dermatol. (2016) PMID: 27038307

Budu-Aggrey A, Bowes J, Löhr S, Uebe S, Zervou MI, Helliwell P, Ryan AW, Kane D, Korendowych E, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Behrens F, Burkhardt H, Hüffmeier U, Ho P, Martin J, Castañeda S , Goulielmos G, Reis A, Barton. Replication of a distinct psoriatic arthritis risk variant at the IL23R locus. Ann Rheum Dis. (2016) PMID: 27016051

Strehl C, Schellmann S, Maurizi L, Hofmann-Amtenbrink M, Häupl T, Hofmann H, Buttgereit F, Gaber T. Effects of PVA-coated nanoparticles on human T helper cell activity. Toxicol Lett. (2016) PMID: 26774940

Smiljanovic B, Stuhlmüller B, Sörensen T, Bonin-Andresen M, Pade S, Backhaus M, Maslinski W, Burmester GR, Radbruch A, Grützkau A, Häupl T. Tissue- and Cell-Specific Transcriptomes Indicate Systemic Nature of RA and Revealed Combinations of Protein Biomarkers Relevant for Disease Characterisation in Serum. Ann Rheum Dis. (2016) Link

Sörensen T, Schulte-Wrede U, Hermann S, Grützkau A, Häupl T. immunoClust based analysis of cytometric profiles reveals immunophenotypic changes in synovial fluid compared to peripheral blood cells in rheumatoid arthritis. Ann Rheum Dis. (2016) Link

Publikationen 2015 Publications 2015

Bowes J, Loehr S, Budu-Aggrey A, Uebe S, Bruce IN, Feletar M, Marzo-Ortega H, Helliwell P, Ryan AW, Kane D, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, Brown MA, Behrens F, Burkhardt H, McHugh N, Huffmeier U, Ho P, Reis A, Barton A. PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. Ann Rheum Dis. (2015) PMID: 25923216

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A. Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nat Commun. (2015) PMID: 26145464

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A. Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nat Commun. (2015) PMID: 25651891

Schleich C, Buchbender C, Sewerin P, Miese F, Aissa J, Brinks R, Schneider M, Antoch G, Ostendorf B. Evaluation of a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) comprising 5 joints (RAMRIS5). Clin Exp Rheumatol. (2015) PMID: 25664925

Stuhlmüller B, Skriner K, Häupl T. Biomarkers for prognosis of response to anti-TNF therapy of rheumatoid arthritis : Where do we stand? Z Rheumatol. (2015) PMID: 26347122

Strehl C, Gaber T, Maurizi L, Hahne M, Rauch R, Hoff P, Häupl T, Hofmann-Amtenbrink M, Poole AR, Hofmann H, Buttgereit F. Effects of PVA coated nanoparticles on human immune cells. Int J Nanomedicine. (2015) PMID: 26056442

Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. immunoClust-An automated analysis pipeline for the identification of immunophenotypic signatures in high-dimensional cytometric datasets. Cytometry A. (2015) PMID: 25850678

Smiljanovic B, Stuhlmüller B, Bonin-Andresen M, Pade S, Backhaus B, Burmester GR, Radbruch A, Grützkau A, Häupl T. The synovial tissue transcriptome reveals combinations of protein biomarkers for unambiguous identification of RA patients from synovial fluid and for quantification of disease activity in serum. Ann Rheum Dis. (2015) Link

Syrbe U, Callhoff J, Conrad K, Poddubnyy D, Haibel H, Junker S, Frommer KW, Muller-Ladner U, Neumann E, Sieper J. Serum adipokine levels in patients with ankylosing spondylitis and their relationship to clinical parameters and radiographic spinal progression. Arthritis Rheumatol. (2015) PMID: 25417763

Poddubnyy D, Haibel H, Braun J, Rudwaleit M, Sieper J. Clinical course over two years in patients with early non-radiographic axial spondyloarthritis and ankylosing spondylitis without anti-tumor necrosis factor alpha treatment: Results from the GErman SPondyloarthritis Inception Cohort (GESPIC). Arthritis Rheumatol. (2015) PMID: 26017497

Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B. Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction. J Renin Angiotensin Aldosterone Syst. (2015) PMID: 25155623

Müller-Lutz A, Schleich C, Sewerin P, Gross J, Pentang G, Wittsack HJ, Antoch G, Schneider M, Ostendorf B, Miese F. Comparison of Quantitative and Semiquantitative Dynamic Contrast-Enhanced MRI With Respect to Their Correlation to Delayed Gadolinium-Enhanced MRI of the Cartilage in Patients With Early Rheumatoid Arthritis. J Comput Assist Tomogr. (2015) PMID: 25340588

Publikationen 2014 Publications 2014

Witt M, Meier J, Hammitzsch A, Proft F, Schulze-Koops H, Grunke M. Disease burden, disease manifestations and current treatment regimen of the SAPHO syndrome in Germany: Results from a nationwide patient survey. Semin Arthritis Rheum. (2014) PMID: 24816195

Kupfer P, Huber R, Weber M, Vlaic S, Häupl T, Koczan D, Guthke R, Kinne RW. Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics (2014) PMID: 24989895

Schwedler C, Kaup M, Petzold D, Hoppe B, Braicu EI, Sehouli J, Ehlers M, Berger M, Tauber R, Blanchard V. Sialic acid methylation refines capillary electrophoresis laser-induced fluorescence analyses of immunoglobulin G N-glycans of ovarian cancer patients. Electrophoresis. (2014) PMID: 24812685

Schwedler C, Kaup M, Weiz S, Hoppe M, Braicu EI, Sehouli J, Hoppe B, Tauber R, Berger M, Blanchard V. Identification of 34 N-glycan isomers in human serum by capillary electrophoresis coupled with laser-induced fluorescence allows improving glycan biomarker discovery. Anal Bioanal Chem. (2014) PMID: 25234305

Poddubnyy D, Conrad K, Haibel H, Syrbe U, Appel H, Braun J, Rudwaleit M, Sieper J. Elevated serum level of the vascular endothelial growth factor predicts radiographic spinal progression in patients with axial spondyloarthritis. Ann Rheum Dis. (2014)PMID: 23956246

Turina MC, Sieper J, Yeremenko N, Conrad K, Haibel H, Rudwaleit M, Baeten D, Poddubnyy D. Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis. Ann Rheum Dis. (2014).PMID: 24845387

Zhou Q, Haupt S, Kreuzer J, Hammitzsch A, Proft F, Neumann C, Leipe J, Witt M, Schulze-Koops H, Skapenko A. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. (2014)

Leipe J, Schramm MA, Prots I, Schulze-Koops H, Skapenko A. Increased Th17 cell frequency and poor clinical outcome in rheumatoid arthritis are associated with a genetic variant in the IL-4R gene, rs1805010. Arthritis Rheum. (2014) PMID: 24403022

Witt MN, Müller F, Weinert P, Nigg AP, Reindl CS, Proft F, Schulze-Koops H, Grunke M. Ultrasound of Synovitis in Rheumatoid Arthritis: Advantages of the Dorsal over the Palmar Approach to Finger Joints. J Rheumatol. (2014) PMID: 24488415

Publikationen 2013 Publications 2013

Poddubnyy D, Haibel H, Listing J, Marker-Hermann E, Zeidler H, Braun J, Sieper J, Rudwaleit M. Cigarette smoking has a dose-dependent impact on progression of structural damage in the spine in patients with axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort (GESPIC). Ann Rheum Dis. (2013)PMID: 23625981

Poddubnyy D, Gaydukova I, Hermann KG, Song IH, Haibel H, Braun J, Sieper J. Magnetic resonance imaging compared to conventional radiographs for detection of chronic structural changes in sacroiliac joints in axial spondyloarthritis. J Rheumatol. (2013)PMID: 23818713

Zhou Q, Haupt S, Prots I, Thümmler K, Kremmer E, Lipsky PE, Schulze-Koops H, Skapenko A. miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. J Immunol (2013) PMID: 23650616

Witt M, Mueller F, Nigg A, Reindl C, Leipe J, Proft F, Stein N, Hammitzsch A, Mayer S, Dechant C, Schulze-Koops H, Grunke M. Relevance of grade 1 gray-scale ultrasound findings in wrists and small joints to the assessment of subclinical synovitis in rheumatoid arthritis. Arthritis Rheum. (2013) PMID: 23553120

Smiljanovic B, Stuhlmüller B, Pade S, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Häupl T. Synovial Tissue Transcriptome and Synovial Fluid Proteome have Stronger Discriminatory Power than Serum in Dissecting Inflammation in RA. Ann Rheum Dis. (2013) Link

Sörensen T, Schulte-Wrede U, Pade S, Hirseland H, Burmester GR, Radbruch A, Grützkau A, Häupl T. Automated and Standardised Analysis for High Dimensional Cytometric Data Provides New Options for Complex Cell-Associated Biomarker Screening. Ann Rheum Dis. (2013) Link

Frisch E, Schwedler C, Kaup M, Iona Braicu E, Gröne J, Lauscher JC, Sehouli J, Zimmermann M, Tauber R, Berger M, Blanchard V. Endo-β-N-acetylglucosaminidase H de-N-glycosylation in a domestic microwave oven: application to biomarker discovery. Anal Biochem. (2013) PMID: 23088875

K Mans, N Tandon, C Sohnrey, S Bolle, A Grützkau, GR Burmester, T Häupl, B Stuhlmüller. Microarray gene expression profiling of rheumatoid arthritis patients for prediction of response to methotrexate treatment. Ann Rheum Dis. (2013) Link

Publikationen 2012 Publications 2012

Heiland GR, Appel H, Poddubnyy D, Zwerina J, Hueber A, Haibel H, Baraliakos X, Listing J, Rudwaleit M, Schett G, Sieper J. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis. (2012) PMID: 22186710

Ramming A, Druzd D, Leipe J, Schulze-Koops H, Skapenko A. Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development. Blood (2012) PMID: 22446486

Poddubnyy D, Rudwaleit M, Haibel H, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J. Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort. Ann Rheum Dis. (2012) PMID: 22459541

Häupl T, Appel H, Backhaus M, Burkhardt H, Grünke M, Grützkau A, Hoppe B, Listing J, Ostendorf B, Rudwaleit M, Sieper J, Skapenko A, Skriner K, Sörensen T, Stuhlmüller B, Zink A, Schulze-Koops H, Burmester GR. Biomarkers in rheumatology: Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research. Z Rheumatol. (2012) PMID: 22546912

Hoppe B, Häupl T, Skapenko A, Ziemer S, Tauber R, Salama A, Schulze-Koops H, Burmester GR, Dörner T. Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation. Ann Rheum Dis. (2012) PMID: 22267327

Tuncel J, Haag S, Carlsén S, Yau AC, Lu S, Burkhardt H, Holmdahl R. MHC class II-Associated response to collagen type XI regulates the chronic development of arthritis in rats. Arthritis Rheum. (2012) PMID: 22391806

Poddubnyy D, Haibel H, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J, Rudwaleit M. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. (2012) PMID: 22127957

Werner SG, Langer HE, Ohrndorf S, Bahner M, Schott P, Schwenke C, Schirner M, Bastian H, Lind-Albrecht G, Kurtz B, Burmester GR, Backhaus M. Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology. Ann Rheum Dis. (2012) PMID: 22388997

Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A. The multifaceted balance of TNF-alpha and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. Journal of molecular medicine (2012) PMID: 22610275

Hoppe B, Dörner T. Coagulation and fibrin network formation: Beyond hemostasis and into inflammation. Nat Rev Rheumatol. (2012) Link

Rubelt F, Sievert V, Knaust F, Diener C, Lim TS, Skriner K, Klipp E, Reinhardt R, Lehrach H, Konthur Z. Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. PLoS One. (2012)PMID: 23226220

Böhm B, Burkhardt H, Uebe S, Apel M, Behrens F, Reis A, Huffmeier U. Identification of low frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization. Arthritis Res Ther. (2012) PMID: 22513239

Ohrndorf S, Fischer IU, Kellner H, Strunk J, Hartung W, Reiche B, Burmester GR, Walther M, Schmidt WA, Backhaus M. Reliability of the novel 7-joint ultrasound score: Results from an inter- and intraobserver study performed by rheumatologists. Arthritis Care Res Hoboken (2012) PMID: 22438306

Hartung W, Kellner H, Strunk J, Sattler H, Schmidt WA, Ehrenstein B, Fleck M, Backhaus M. Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: one year of experience in daily clinical practice. Arthritis Care Res Hoboken (2012) PMID: 22183834

Miese F, Buchbender C, Scherer A, Wittsack HJ, Specker C, Schneider M, Antoch G, Ostendorf B. Molecular imaging of cartilage damage of finger joints in early rheumatoid arthritis with delayed gadolinium-enhanced magnetic resonance imaging. Arthritis Rheum. (2012) PMID: 21952736

Publikationen 2011 Publications 2011

Hoppe B, Burmester GR, Häupl T. Prothrombin 20210G>A genotype and C-reactive protein level. Blood (2011) PMID: 22021457

Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R. Crystal structure of an arthritogenic anticollagen immune complex. Arthritis Rheum. (2011) PMID: 22127694

Hoffmann MH, Skriner K, Herman S, Baumann C, Steiner CW, Ospelt C, Meyer B, Gleiss A, Pfatschbacher J, Niederreiter B, Tuncel J, Zanoni G, Steiner G. Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis. J Autoimmun. (2011) PMID: 21439786

Ohrndorf S, Hensch A, Naumann L, Hermann KG, Scheurig-Münkler C, Meier S, Burmester GR,Backhaus M. Contrast-enhanced ultrasonography is more sensitive than grayscale and power Doppler ultrasonography compared to MRI in therapy monitoring of rheumatoid arthritis patients. Ultraschall Med. (2011) PMID: 22052070

Finzel S, Ohrndorf S, Englbrecht M, Stach C, Messerschmidt J, Schett G, Backhaus M. A detailed comparative study of high-resolution ultrasound and micro-computed tomography for detection of arthritic bone erosions. Arthritis Rheum. (2011) PMID: 21538312

Poddubnyy D, Rudwaleit M, Haibel H, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis. (2011) PMID: 21622969

Leipe J, Schramm M, Baeuerle M, Dechant C, Grunke M, Witt M, Nigg A, Reindl C, Schulze-Koops H, Skapenko A. Interleukin-22 serum levels are associated with clinical outcome in rheumatoid arthritis. Ann Rheum Dis. (2011) Link

Poddubnyy D, Conrad K, Ruiz-Heiland G, Syrbe U, Haibel H, Appel H, Rudwaleit M, Schett G, Sieper J. Predictive and protective value of biomarkers in patients with ankylosing spondylitis who are at high risk of radiographic spinal progression. Arthritis Rheum. (2011) Link

Publikationen 2010 Publications 2010

Stuhlmüller B, Häupl T, Hernandez MM, Grützkau A, Kuban RJ, Tandon N, Voss JW, Salfeld J, Kinne RW Burmester GR. CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clinical pharmacology and therapeutics. (2010) PMID: 20032971

Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Lascorz J, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H*, Barton A*, Reis A* (*equal contribution). Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet. (2010) PMID: 20953186

Poddubnyy D, Rudwaleit M, Listing J, Braun J, Sieper J. Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis. Ann Rheum Dis. (2010) PMID: 20498207

Miese FR, Ostendorf B, Wittsack HJ, Reichelt DC, Mamisch TC, Zilkens C, Lanzman RS, Schneider M, Scherer A. Radiology. Metacarpophalangeal joints in rheumatoid arthritis: delayed gadolinium-enhanced MR imaging of cartilage-a feasibility study. (2010) PMID: 20807848

Smiljanovic B, Grün JR, Steinbrich-Zöllner M, Stuhlmüller B, Häupl T, Burmester GR, Radbruch A, Grützkau A, Baumgrass R. Defining TNF-α- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease. J Mol Med. (2010) PMID: 20640394

Häupl T, Stuhlmüller B, Grützkau A, Radbruch A, Burmester GR. Does gene expression analysis inform us in rheumatoid arthritis? Ann Rheum Dis. (2010)PMID: 19995742

Stuhlmüller B, Häupl T, Hernandez MM, Grützkau A, Kuban RJ, Tandon N, Voss JW, Salfeld J, Kinne RW, Burmester GR. CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clin Pharmacol Ther. (2010) PMID: 20032971

Publikationen 2009 Publications 2009

Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Herrmann M, Müller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, Sieper J, Schett G. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum. (2009) PMID: 19877044

Backhaus M, Ohrndorf S, Kellner H, Strunk J, Backhaus TM, Hartung W, Sattler H, Albrecht K, Kaufmann J, Becker K, Sörensen H, Meier L, Burmester GR, Schmidt WA. Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project. Arthritis Rheum. (2009) PMID: 19714611

Hoppe B, Häupl T, Egerer K, Gruber R, Kiesewetter H, Salama A, Burmester GR, Dörner T. Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. Ann Rheum Dis. (2009) PMID: 18633125

Generini S, Steiner G, Miniati I, Conforti ML, Guiducci S, Skriner K, Kaloudi O, Giacomelli R, Smolen J, Matucci-Cerinic M. Anti-hnRNP and other autoantibodies in systemic sclerosis with joint involvement. Rheumatology Oxford (2009) PMID: 19483090

Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure.Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. (2009) PMID: 19204106

Menssen A, Edinger G, Grün JR, Haase U, Baumgrass R, Grützkau A, Radbruch A, Burmester GR, Häupl T. SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data. BMC Genomics. (2009) PMID: 19265543